The IGCA Health Database was created for IG owners and breeders to make an honest and open effort to share information about IGs affected with conditions known, or suspected, to be genetic in nature. These include the following conditions:  
Eyes :

Cataracts, Vitreous Degeneration or Progressive Retinal Atrophy (PRA) Documentation needed: CERF or letter from Board Certified Ophthalmologist, GlaucomaDocumentation needed: Letter from Veterinary including documented elevated intraocular pressure (>30 mm HG), Lens Luxation Documentation needed: Letter from Board Certified Ophthalmologist Veterinarian, Optic Nerve HypoplasiaDocumentation needed: Letter from Board Certified Ophthalmologist Veterinarian.

Italian Greyhounds 10 years and older- IG's who have had a CERF exam at age 10 or older who are not affected with PRA, do not have a CERF certificate, but must share any eye condition they may have.

Internal Medicine: von Willebrand's disease (vWD) Documentation needed: Results from Lab for vWD factor or Letter from Veterinarian.  

Skeletal: Legg-Perthe's Disease (LPD), Luxating Patellas or Hip Dysplasia. Documentation needed: OFA results or Letter from Veterinarian.

Dental: Familial Enamel Hypoplasia (FEH)- Documentation needed: Results from UC Davis. You may list all results that include affected, carriers or clears.
Autoimmune Diseases:
Addison Disease (Hypoadrenocorticism) Documentation needed: Flatline ACTH stim test, Please include the age of onset of the disease.

Pemphigus Foliaceus/Erythematosis/Vulgaris - Documentation needed: Histopath of skin. Please include the age of onset of the disease

Lymphocytic Orchitis-  Documentation needed: Histopath of affected testicle. Please include the age of onset of the disease.

Hypothyroidism or Immune Mediated Thyroiditis -Documentation needed: positive TGAA test. Please include the age  of onset of the disease.

Masticatory Muscle Myositis (MMM) - Documentation needed: Positive 2M muscle fiber test. Please include the age of onset of the disease.

Immune Mediated Polyarthritis (IMP)-  Documentation needed: Joint Tap and a negative tick titer panel Lymes/RMSF/Erlichia. Please include the age of onset of the disease.

Immune Mediated Hemolytic Anemia (IMHA)- Documentation needed: Letter from Veterinarian saying IG was treated for presumptive IMHA based on ruling out other causes and positive response to immune suppressive medications OR CBC (Complete Blood Count) with evidence of anemia AND spherocytes OR copy of Vet record showing positive autoagglutination test. Please  include the age of onset of the disease.

Immune-Mediated Thrombocytopenia (ITP). Documentation needed: copy of CBC showing low platelets AND neg Ehrilchia/lyme/rmsf titers; OR a letter from Veterinarian saying IG was treated for presumed ITP, no underlying causes were found, and the dog had a positive response to immune suppressive medication. Please include age of the onset of the disease.

Steroid responsive Meningitis - Documentation needed: Spinal tap results. Please include the age of the onset of the disease.

Pedigrees of dogs proven to be affected with these conditions will be placed in the database after the owner completes the following steps:

  1. Fill out and sign the release form Word  doc <>  or pdf file <javascript:;> .  
  2. Provide documentation of the diagnosis  
  3. Provide a copy of your dog's pedigree if not AKC  registered
  4. Please download and complete the release form  waiver. Send the release form waiver, along with a copy of the test results  to:
  5. Lynette Coyner
  6. PO Box 129
  7. Larkspur, CO 80118  
  8. NOTE: Adobe Reader is needed to view and print PDF files.  
  9. Click here for the FREE Adobe Reader download. <>  

Pedigrees of Affected Italian Greyhounds

This site is an effort to give anyone willing to participate an opportunity to try to improve the health of future generations of IG's. This is a chance for everyone to help build a pedigree database of IG's affected with conditions that are believed to be inherited. There are numerous articles on this site about conditions affecting Italian greyhounds, and we highly recommend that you read everything included in the health section.

Sharing this information may give us insight towards the modes of inheritance of these diseases. It also allows breeders to make informed decisions about potential breedings they are planning. Ideally, we would have DNA tests to identify carriers of genetic diseases. Right now, those do not exist for IG's. So pedigrees such as these provide breeders valuable information about the status of dogs related to their own dogs, or related to dogs they are considering using in their breeding program.

Modes of inheritance of these conditions have not been definitively established in IGs. Most are believed to be autosomal recessives (simple recessives) unless otherwise noted.

Click the links below for the pedigrees of dogs affected with each condition. An asterisk "*" on the pedigree denotes that the individual is a Top Producer.

Progressive Retinal Atrophy (PRA) <>
Legg-Perthe's Disease (LPD)
Vitreous Degeneration <>
Luxating Patellas (slipped stifles) <>
Cataracts <>
Immune Mediated Thyroiditis Disease <>
von Willebrand Disease (vWD) <>
Hip Dysplasia <>
Optic Nerve Hypoplasia
Luxating Lens
IGs 10 Years and Older
Familial Enamel Hypolplasia (FEH)
Addison Disease
Pemphigus Foliaceus/Erythematosis/Vulgaris
Lymphocytic Orchitis
Masticatory Muscle Myositis (MMM)
Idiopathic Immune-mediated Polyarthritis (IMP)
Immune Mediated Hemolytic Anemia (IMHA)
Immune Mediated Thrombocytopenia (ITP)
Steroid Responsive Meningitis
Progressive Retinal Atrophy (PRA)
PRA is an inherited condition known to occur in many breeds of dogs. The initial onset of disease occurs at different ages in different breeds of dogs. Dogs with PRA gradually lose eyesight due to degeneration of the retina. There is no treatment for PRA. The mode of inheritance of PRA has yet to be proven in Italian Greyhounds, but it appears to be a simple recessive.

Dogs Affected With PRA:

Amelia Blue Moon <javascript:;>  - Generalized Retinal Atrophy
Banzai Nexus Aurora Borealis <javascript:;>  

Bo-Bett's Sonata Tator To <> t - Bilateral PRA
Cincris Milo Insall <javascript:;>  
Fox Hedge Fezziwig <javascript:;>  - Diagnosed in 1997. Retinal degeneration present in both eyes.
Hi Country Grace Walker <javascript:;>  - Generalized Retinal Atrophy
Littleluv Regatta Di Mare <javascript:;>  - Bilateral retinal atrophy
Logos Stairway to Heaven <javascript:;>
Loranne Spring's Magic Moment <javascript:;>  - Generalized Retinal Atrophy Both Eyes
Marchwind Mystical Magic <javascript:;>  
Marchwind Summer Sunset <javascript:;>  - Fundus: retinal atrophy generalized both eyes
Mira Cameo Appearance <javascript:;>  - Fundus: retinal atrophy generalized both eyes
Mira Now Voyager <javascript:;>  
Shalamar Savvy Sebastian <javascript:;>  
Sonata Desperado Of Silaos <javascript:;>  - Generalized Retinal Atrophy
Viva Elan's Panache* <javascript:;>  
Viva's The Dance* <javascript:;>  
Whirlwind The One and Only <javascript:;>  
Zack <javascript:;>  

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Legg-Perthe's Disease (LPD)

LPD is also known as Legg-Calve-Perthe's disease and aseptic necrosis of the femoral head. The blood supply to the head of the femur deteriorates and the bone dies. Typically the disease appears between 4 and 12 months of age. Males and females are equally affected and often only one hip is affected. The mode of inheritance is difficult to determine but may be an autosomal recessive trait with incomplete penetrance.

Dogs Affected with Legg-Perthe's Disease (LPD):

Dante Capucetta Rosa <javascript:;>
Hi Country Midnight Walker <javascript:;>  

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Vitreous Degeneration

The vitreous is the largest physical structure in the eyeball. It is located inside of the eyeball just behind the lens but in front of the retina. It is a firm jelly like structure and crystal clear. All of the light that enters the eye to be shown on the retina must first pass through the vitreous. Over time there is a normal age related degradation of this structure that changes its physical character. It causes the vitreous to become more fluid in consistency and cloudy.

Degeneration of the vitreous humor of the eye is a normal aging change in all dogs and normally does not progress to any significant degree. Italian greyhounds often have degeneration at a very young age. The long-term effects of this are not known, nor is the method of inheritance.

Dogs affected with vitreous degeneration are considered "breeder's option" by CERF. Affected dogs are issued CERF numbers. Their CERF certificates will contain the notation that vitreous degeneration is present.

Dogs Affected With Vitreous Degeneration:

Alveare's Double Stuff <javascript:;>  - Vitreous degeneration Left eye lens, Ant Cortex Interior
Anji Rohan Showdown Budgie <javascript:;>  - Vitreous degeneration syneresis & anterior chamber both eyes
Anji St Bardo <javascript:;>  
Blackacre L'Image Mo' Better Blues <javascript:;>  
Blackacre Little Hanky Panky  <javascript:;>
Bojangles Daddy Long Legs <javascript:;>  - Vitreous degeneration/syneresis both eyes
Bonafide Heart Mender  <javascript:;>
Brio Uwharrie Lightkeeper <javascript:;>  
Cantell Amorous Blu Damaris <javascript:;>  - Vitreous Degeneration
Croix and Como Read All About It <javascript:;>  - Vitreous degeneration right eye anterior chamber, syneresis
D'Folly Bit of Sushi Jo Na Da <javascript:;>  - Vitreous Degeneration anterior chamber left eye
Diavolino Touch This At Zia <javascript:;>  
Donmar Ballarina Ribbons <javascript:;>  
Donmar Scarlet Ribbons* <javascript:;>  
Donmar Tracery Ribbons <javascript:;>  
Equus Logos In The Beginning <javascript:;>  - Vitreous degeneration/syneresis
Izat Good Will Hunting <javascript:;>  
Izat Play The Game <javascript:;>  
Izat Simply Irresistible <javascript:;>  
Jo Na Da Bye Bye Love D'Folly <javascript:;>  - Vitreous Degeneration
Jo Na Da Keeper Of The Crown <javascript:;>  - Vitreous Degeneration Ant Chamber Rt eye
Jo Na Da's Love Letters <javascript:;>  - Vitreous Degeneration
Kato Blackacre Earth Angel  <javascript:;>
Kato-Blackacre Autumn Attire <javascript:;>  
Kato-Blackacre Superstition <javascript:;>  
Kimson Best Man <javascript:;>  - Vitreous Degeneration
Kimson Laguna Home Run  <javascript:;>
Laguna Imaje Trump Card <javascript:;>  
Levi Five O One Blue <javascript:;>  - Vitreous degeration syneresis
Logos Authority Over The Enemy <javascript:;>  - Vitreous degeneration/syneresis anterior chamber both eyes
Logos Rocking The Gates of Hell <javascript:;>  - Vitreous degeneration/syneresis anterior chamber both eyes
Loranne Spring's Magic Moment <javascript:;>  - Vitreous Degeneration (Syneresis) both eyes
Marlord Rohan Poetic Justice <javascript:;>  - Vitreous degeneration syneresis Anterior chamber
Misty Vale Rainbow High <javascript:;>  
Ozio Sambuca Di Virtu <javascript:;>  - Vitreous Degeneration Anterior chamber
Raindance The Sky Is Falling <javascript:;>  - Vitreous Degeneration Anterior Chamber
Retaggio Starry Night <javascript:;>  - Vitreous Degeneration
Rohan Anji Call Me Mr Orca <javascript:;>  
Rohan Cascata Di Luce <javascript:;>  - Vitreous Degeneration/Syneresis Both eyes
Rohan Jovani Hot Tamale <javascript:;>  
Suez Sweet Revenge At Kismet <javascript:;>  
Uwharrie Yeshua Final Four <javascript:;>  
Viva Sonata Painted Desert <javascript:;>

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Luxating Patellas (slipped stifles)

Luxated patellas are a congenital (present at birth) condition. The actual luxation may not be present at birth, but the structural changes which lead to luxation are present. The patellas (knee caps) do not stay in the proper location. Most researchers believe luxated patellas to be heritable though the exact mode of inheritance is not known. The condition is commonly seen in Italian Greyhounds.

Dogs Affected with Luxated Patellas:

Ankhu Mystical Wonderlust <javascript:;>  - Bilateral Medial Patellar Luxation Grade 1
Beppo <javascript:;>  - Left Grade 1 Medially Luxating Patella Right Grade 2 Medially Luxating Patella
Kimson Daydream Believer <javascript:;>  - Medially luxating patellas (bilateral)
Raindance Under Starry Skies <javascript:;>  - Bilateral Medial Patellar Luxation Grade 1
Sirius Precious <javascript:;>  - Bi Lateral  Medial Intermittent Grade 2 Luxated patellas
Te Awa Vanilla Secret <javascript:;>  
Viva Sonata Painted Desert <javascript:;>  - Left Grade 1 Medially Luxating Patella
Willow Wild Whispering Wind <javascript:;>  - Bilateral Iintermittent Grade 2

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A cataract is an opacity in the lens of the eye. Senile cataracts occur in geriatric dogs and are considered a product of aging, as is ãnuclear sclerosisä a haziness resulting from thickening of the lens with age.

Cataracts in younger dogs are often due to genetic causes, but can also be caused by trauma, ocular inflammation, diabetes mellitus, genetic retinal atrophy, persistent pupillary membranes, persistent hyaloid remnants, specific nutritional deficiencies, congenital abnormalities and uncommonly by other specific metabolic diseases. Cataracts that are present at birth (congenital cataracts) or that develop before about four to six years of age (juvenile cataracts) should be considered highly suspicious of being hereditary, particularly if both lenses are similarly affected and no predisposing condition is known. In these cases, related dogs should be examined to determine if other family members are affected

The area of the lens that develops a cataract is highly variable. Cataracts may be very small and not affect vision, or may involve the entire lens and cause blindness. Some progress very rapidly after they appear, others remain quite small indefinitely. In some breeds, well established patterns of inherited cataracts are known. The cataracts have a typical appearance, age of onset and location within the lens. In sporting breeds, cataracts are often suspected as being inherited as autosomal dominant with incomplete penetrance, but in most other breeds where the mode of inheritance is known cataracts are inherited in an autosomal recessive manner.

No specific type of inherited cataract has been identified in Italian greyhounds. While many inherited cataracts develop by about 4-6 years of age, breeders have reported families of dogs affected with apparently inherited cataracts that are manifested later in life.

Dogs Affected with Cataracts:

We have elected to list any dog submitted that has been diagnosed with cataracts. It is not always known which cataracts are inherited in nature and which might be due to disease or trauma. If an examining ophthalmologist indicates the "significance of this punctate cataract is unknown" then the dog can still be issued a CERF number. In light of this, we have attempted to provide as much information as we have on the location of the cataract within the lens, age at diagnosis and CERF status of the dog.

Adriana Gold Crown <javascript:;>  - Left anterior equatorial Right equatorial Also noted corneal dystrophy and vitreous degeneration
Anji Rohan Showdown Budgie <javascript:;>  - Corneal dystrophy epithelial/stromal both eyes Lens equatorial cortex intermediate left eye
Anji St Bardo  <> - Cataract both eyes Generalized.
Bojangles Daddy Long Legs <javascript:;>  - Puncate left eye, significance unknown
Bonafide Heart Mender <javascript:;>  - Left Anterior Cortex Intermediate
Cantell Amourous Blu Damaris <javascript:;>  - Both eyes
Hi Country Midnight Walker <javascript:;>  - Both eyes Nucleus Senile
Infiniti Genica Sorcerers Apprentice <javascript:;>  - Punctate Cataract Posterior Cortex Left Eye
Izat Simply Scandalous <javascript:;>  - Punctate cataract Right eye anterior cortex and posterior cortex
KC Paint the Sky with Stars <javascript:;>  - Both eyes Nuclear Age at onset 2 years
Kimson Best Man <javascript:;>  - Intermediate Posterior Sutures Cornea Dystrophy epithelial/stomal Both eyes
Laguna Imaje Trump Card <javascript:;>  - Posterior Sutures Both Eyes
Levi Five O One Blue <javascript:;>  - Both eyes Intermediate anterior cortex and equatorial cortex
Ozio Sambuca Di Virtu <javascript:;>  - Both Eyes Punctate
Rohan Jovani Hot Tamale <javascript:;>  - Both Eyes Intermediate Anterior Sutures & Posterior Sutures
Sierra Vue Crown Jewel  <javascript:;> - Left Intermediate Posterior Cortex
Sonata Desperado Of Silaos <javascript:;>  - Cataract Anterior Cortex Diffuse
Whirlwind Blew By You <javascript:;>  - Left anterior equatorial Right equatorial Originally diagnosed as punctate at 5 years of age. At 8.5 years of age, left eye is 1/3 affected and dog did not CERF for the first time.
Whirlwind Ice Cold Beer <javascript:;>  - Right punctate capsular at 3.5 years of age. Now 5.5 years of age, cataract is unchanged. Dog presently has a CERF number.
Whirlwind Tip of the Iceberg <javascript:;>  - Left anterior cortex and equatorial cortex Right anterior cortex and equatorial cortex Diagnosed as punctate at 4 years of age. At 8.5 years of age, both are intermediate and dog did not CERF for the first time.
Willow's Song of Angels <>  - Cataract, left eye, age of onset 7 yrs.

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von Willebrand Disease (vWD)

Like other bleeding diseases, vWD is characterized by hematomas, intermittent lameness (from bleeding into the joints) and nosebleeds. Affected dogs are deficient in clotting factor VIII activity. DNA tests exist for vWD in several breeds, but not Italian greyhounds. Mode of inheritance in those breeds is autosomal recessive.

Since no DNA test exists for IG's we must rely on the blood test for von Willebrand's factor (vWF) in our breed. The results for this test are not always 100% reproducible and there is a lot of overlap in result value for normal, carrier and affected dogs. Therefore we have elected to list any reported vWD test results that owners have submitted. Higher values are better, please see the vWD articles on this site for more information.

von Willebrand's Disease Test Results:

Please note we have elected to list all results that have been shared with us, those that fall within normal as well as abnormal ranges. Higher values are better. Please see the other vWD articles on this site for more information.

Agape Big Shot Bravo <javascript:;>  - vWF 97%
Anji Pineridge St John <javascript:;>  - vWF 54%
Anji Rohan Miss Fantan <javascript:;>  - vWF 74%
Anji RU Ready For This <javascript:;>  - vWF 59%
Anji St Amand <javascript:;>  - vWF 73%
Anji St Bardo <javascript:;>  - vWF 80%
Anji St Felix <javascript:;>  - vWF 89%
Anji St Philemon <javascript:;>  - vWF 61%
Anji St Senan <javascript:;>  - vWF 118%
Bo Bett Adam Almandine <javascript:;>  - vWF 12%
Dante Prepare TB Impressed <javascript:;>  - vWF 6%
Dolce Dramatic Liberator <javascript:;>  - vWF 88%
Donmar Ballarina Ribbons <javascript:;>  - vWF 61%
Equus A Fortune In Fudge <javascript:;>  - vWF 83%
Equus I Want It Now <javascript:;>  - vWF 79%
Equus Logos In The Beginning <javascript:;>  - vWF 126%
Genica Bibbidi Bobbidi Boo <javascript:;>  - vWF 91%
Heza Fast Man dob Mann <javascript:;>  - vWF 63%
India Elizabeth Moriority Paw Kuh <javascript:;>  - vWF 129%
Izat Ready When You Are <javascript:;>  - vWF 106%
Jo Na Da Bye Bye Love D'Folly <javascript:;>  - vWF 126%
Jo Na Da Kiss N Tell D'Folly <javascript:;>  - vWF 94%
Kappri Amy Lou Of Orion <javascript:;>  - vWF 17%
Kappri Milo <javascript:;>  - vWF 6%
Kappri Minipearl <javascript:;>  - vWF 16%
Kappri Sahara Goose Oh <javascript:;>  - vWF 19%
Kimson Laguna Home Run <javascript:;>  - vWF 46%
Lakeside Anji St Nicholas <javascript:;>  - vWF 46%
Layne Little Light Of Mine <javascript:;>  - vWF 7%
Levi Five O One Blue <javascript:;>  - vWF 165%
Logos Authority Over The Enemy <javascript:;>  - vWF 105%
Madison Charisma County Coop-puh <javascript:;>  - vWF 83%
Maggie Sue Coop-Puh <javascript:;>  - vWF 91%
Mystic Blu Willow <javascript:;>  - vWF 78%
Orion Tiny Treasure <javascript:;>  - vWF 17%
Ozio Sambuca Di Virtu <javascript:;>  - vWF 70%
Perky Emma Louise Paw Kuh <javascript:;>  - vWF 132%
Pineridge Evening Primrose <javascript:;>  - vWF 162%
Pineridge Sweet Cicily <javascript:;>  - vWF 48%
Pineridge Texas Bluebonnet <javascript:;>  - vWF 52%
Rococo Love Is Blonde <javascript:;>  - vWF 93%
Rococo Rainbow Warrior <javascript:;>  - vWF 92%
Rococo Shanghai Shimmer  <javascript:;> - vWF 93%
Rococo Take It For Granite <javascript:;>  - vWF 142%
Rococo Visions Of Sugarplums <javascript:;>  - vWF 132%
Rohan Cascata Di Luce <javascript:;>  - vWF 194%
Rohan Jovani Hot Tamale <javascript:;>  - vWF 66%
Rohan Ready Set Go Go Go* <javascript:;>  - vWF 61%
Rohan Saint Jolenta <javascript:;>  - vWF 88%
Silaos Sara at Fox Hedge <javascript:;>  - vWF 120%
Viva Sonata Breakaway <javascript:;>  - vWF 99%
Whirlwind Blew By You <javascript:;>  - vWF 86%
Whirlwind Blew By You Too <javascript:;>  - vWF 104%
Whirlwind Ice Cold Beer  <javascript:;> - vWF 87%
Whirlwind Ice Cream Sandwich <javascript:;>  - vWF 95%
Whirlwind Tip of the Iceberg <javascript:;>  - vWF 118%

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Hip Dysplasia

Hip dysplasia literally means an abnormality in the development of the hip joint. It is characterized by a shallow acetabulum (the "cup" of the hip joint) and changes in the shape of the femoral head (the "ball" of the hip joint). Dogs with hip dysplasia appear to be born with normal hips and then to develop the disease later. This has led to a lot of speculation as to the contributing factors which may be involved with this disease. This is an inherited condition, but not all dogs with the genetic tendency will develop clinical signs and the degree of hip dysplasia which develops does not always seem to correlate well with the parent's condition. Hip dysplasia is not believed to be a common condition in IGâs but is very common in many larger breeds.

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Glaucoma is increased pressure within the eye (intraocular pressure = IOP). Cells inside the eye produce a clear fluid ("aqueous humor") that maintains the shape of the eye and nourishes the tissues inside the eye. (Note: aqueous humor is NOT the same fluid as tears. Tears bathe the outside surface of the eye. Aqueous humor circulates inside the eye. These two fluids do not interact). The aqueous humor drains out of the eye into the bloodstream through the drainage angle–a sieve or meshwork-like area through which aqueous percolates out of the eye. The balance of aqueous fluid production ("the faucet") and drainage ("the drain in the sink") is responsible for maintaining normal pressure inside the eye. In glaucoma, the drain becomes partially or completely clogged but the "faucet" steadily keeps producing aqueous, causing pressure to build inside the eye. If untreated, this increased pressure usually causes irreversible blindness, in addition to stretching and enlargement of the eye.

Dogs affected with Glaucoma:

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Optic Nerve Hypoplasia- Optic nerve hypoplasia is a condition that uncommonly affects the optic nerves of cats and dogs, leading to a variable degree of vision reduction (or even blindness) in one or both eyes.

Dogs affected with Optic Nerve Hyplasia:

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Lens Luxation
is the dislocation or displacement of the lens within the eye. The lens is the clear structure in the eye, consisting of two rounded or convex surfaces, that focuses light rays to form an image onto the retina. Normally the lens is suspended between the iris (the colored portion of the eye) and the vitreous (the clear gel in the back of the eye), and is held in place by small fibers called zonules or suspensory ligaments.
Dogs affected with Lens Luxation:

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Italian Greyhounds 10 years and older
 IG's who have had a CERF exam at age 10 or older who are not affected with PRA, do not have a CERF certificate, but must share any eye condition they may have.  
IGs 10 years and Older and eye conditions:  

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Familial Enamel Hypoplasia (FEH) Autosomal recessive amelogenesis imperfecta (ARAI)
is an inherited genetic disorder of tooth enamel that occurs in Italian Greyhounds. It is commonly known to breeders as Familial Enamel Hypoplasia (FEH). It is characterized by enamel pitting and tooth discoloration; often teeth are unusually small, pointed and prone to increasing gaps between teeth with age. There appears to be no association of FEH with periodontitis. Dr. Niels Pedersen and his research group at the School of Veterinary Medicine, University of California-Davis identified the mutation associated with FEH in Italian Greyhounds.  It is estimated that 14% of Italian Greyhounds are affected with FEH and 30% are carriers.
Dogs affected with Familial Enamel Hypoplasia (FEH) AND Dogs that are carriers or clear:

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Autoimmune Diseases:
Autoimmune diseases have become more prevalent in IG's in recent years. There is evidence to support a genetic cause for autoimmune diseases in this breed, but given that the average age of onset is approximately 8 years, environmental factors are also likely to play a role, especially in later onset cases. We are listing here only those AI diseases with definitive diagnostic tests. Please remember to include the age of onset of the disease.

Addison's Disease or also know as Hypoadrenocorticism : Mineralocorticoids and glucocorticoids are hormones normally produced by the adrenal glands, which are located near the kidneys. Both of these hormones are critical to the healthy functioning of the body, and an abnormal increase or decrease of either of these hormones can lead to serious health problems if not addressed in time. Hypoadrenocorticism is characterized by a deficient production of glucocorticoids and/or mineralocorticoids. Deficient production of both these hormones can cause a number of symptoms like weakness, dehydration, low blood pressure, depression, heart toxicity, vomiting, blood in feces, and weight loss.
Dogs affected with Addison's Disease:

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is the general designation for a group of autoimmune skin diseases involving ulceration and crusting of the skin, as well as the formation of fluid-filled sacs and cysts (vesicles), and pus filled lesions (pustules). Some types of pemphigus can also affect the skin tissue of the gums. An autoimmune disease is characterized by the presence of autoantibodies that are produced by the system, but which act against the body's healthy cells and tissues -- just as white blood cells act against infection. In effect, the body is attacking itself. The severity of the disease depends on how deeply the autoantibody deposits into the skin layers.

Dogs affected with Pemphigus Foliaceus/Erythematosis/Vulgaris:

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Lymphocytic Orchitis is autoimmune destruction of the sperm producing cells of the testicle leading to sterility.

Dogs affected with Lymphocytic Orchitis :

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Hypothyroidism or Immune Mediated Thyroiditis is an endocrine disease that is characterized by a deficiency of thyroid hormones.The disease has variable onset, but tends to appear at 2 to 5 years of age. Dogs may be clinically normal for years, only to become hypothyroid at a later date. As a result of the variable onset of the presence of autoantibodies, periodic testing is necessary. Since the majority of affected dogs will have autoantibodies by 4 years of age, annual testing for the first 4 years is recommended. After that, testing every other year should suffice.Inheritance of this disease is believed to be autosomal recessive.

Dogs affected with Immune Mediated Thyroiditis:

Misty Vale Beauty School Drop Out <javascript:;>  - Compensated Autoimmune Thyroiditis
Sophia Loren <javascript:;>
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Masticatory muscle myositis (MMM) is an inflammatory condition involving the muscles of mastication or chewing in the dog. MMM is caused by an immune mediated process targeted against 2M muscle fibers which are present in the muscles of mastication, the cause of which is unknown.

Dogs affected with Masticatory Muscle Myositis:  

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Idiopathic Immune-Mediated Polyarthritis (IMP) is caused by an abnormal immune system response. The joints of one, or typically, multiple joints are identified as abnormal and an inflammatory reaction occurs with increased numbers of white blood cells entering the joint space. The white blood cells, themselves, release various chemical mediators that create further swelling and inflammation. Joint pain and many times fever are noted due to the inflammatory response.

Dogs affected with Immune Mediated Polyarthritis (IMP):

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Immune mediated hemolytic anemia (IMHA), also known as auto-immune mediated hemolytic anemia (AIHA),
is a disease in which the body's immune system, which is designed to attack and kill germs, attacks and kills the body's own red blood cells. The attack begins when antibodies, which are molecules made by the immune system to target germs, instead attach to and target the animal's own red blood cells for destruction.
Dogs affected with Immune Mediated Hemolytic Anemia (IMHA):

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Immune-Mediated Thrombocytopenia (ITP)
refers to an abnormally low blood-concentration of platelets, which are blood cells that promote blood clotting after injury to the lining of the blood vessels. When the concentration of platelets becomes too low, bruising and bleeding may occur. Dogs with blood platelet concentrations of less than 40,000 per microliter of blood are at risk for spontaneous bleeding.
Dogs affected with Immune-Mediated Thrombocytopenia (ITP):

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Steroid Responsive Meningitis
is a condition that involves a dog's central nervous system. Meningitis means inflammation of the meninges, the covering layer of the central nervous system. The condition is referred to as SRMA, or steroid responsive meningitis-arteritis because it affects the arteries in many body system tissues as well.

Dogs affected with Steroid responsive Meningitis:


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